Blunted Non‐Shivering Thermogenesis in Obese Relative to Non‐Obese Adult Males
نویسندگان
چکیده
منابع مشابه
Introduction Nonshivering Thermogenesis (nst) Is a Crucial Cold- Defense Mechanism in Newborn and Some Adult
NONSHIVERING THERMOGENESIS (NST) IS A CRUCIAL COLDDEFENSE MECHANISM IN NEWBORN AND SOME ADULT RODENTS.1,2 The thermal state of brown adipose tissue (BAT) varies on a circadian4,5 as well as on an ultradian6,7 basis when sleep occurs. The sleep-related changes in the functioning of BAT have rarely been investigated; when the changes were studied in small rodents, coldinduced NST was found to ope...
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Prolonged maternal separation inhibits endogenous heat production in infant mammals exposed to cold. This inhibition of thermogenesis occurs many hours before energy stores have been fully depleted. The need to protect energy resources during separation-induced starvation may be signaled by declining levels of leptin, a hormone that acts as a "fat signal" and a regulator of energy utilization; ...
متن کاملImplications of nonshivering thermogenesis for energy balance regulation in humans.
The incidence of the metabolic syndrome has reached epidemic levels in the Western world. With respect to the energy balance, most attention has been given to reducing energy (food) intake. Increasing energy expenditure is an important alternative strategy. Facultative thermogenesis, which is the increase in energy expenditure in response to cold or diet, may be an effective way to affect the e...
متن کاملRunning head: Basis of nonshivering thermogenesis in E. myurus
The molecular and biochemical basis of non-shivering thermogenesis in an African 1 endemic mammal, Elephantulus myurus 2 3 Nomakwezi Mzilikazi*, Martin Jastroch, Carola W Meyer and Martin Klingenspor 4 *To whom correspondence should be addressed 5 Department of Zoology, Nelson Mandela Metropolitan University, P.O. Box 77000, Port 6 Elizabeth, 6031, SOUTH AFRICA 7 Email: nomakwezi.mzilikazi@nmmu...
متن کاملOnly UCP1 can mediate adaptive nonshivering thermogenesis in the cold.
Adaptive nonshivering thermogenesis may have profound effects on energy balance and is therefore therefore is a potential mechanism for counteracting the development of obesity. The molecular basis for adaptive nonshivering thermogenesis has remained a challenge that sparked acute interest with the identification of proteins (UCP2, UCP3, etc.) with high-sequence similarity to the original uncou...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2015
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.29.1_supplement.lb667